Testing of a Tetravalent Dengue Vaccine in a Non-human Primate Model
In order to produce a viable Dengue vaccine it must contain all four serotypes of the virus -- Dengue 1,2,3 and 4. Following the successful non-human primatetrials on their Dengue 2 vaccine candidates, Arbovax is in the process of producing stable deletion mutants of Dengue 1,3,and 4 that exhibit the required host-range characteristics. These four serotypes must them be put together to produce a tetravalent vaccine that balances out the immunogenicity of each individual component.
This is a pivotal trial for the company as it represents the ultimate proof of principle for the technology.